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The brain is constituted by a preponderance of microglia and astrocytes, these glial cells are essential in the Central Nervous System (CNS), with microglia functioning as innate immune cells involved in surveillance and defense, while astrocytes modulate neuronal communication, maintain the extracellular environment, and regulate inflammatory signaling (Garland et al., 2022) Both brain cells are able to produce pro- and anti-inflammatory cytokines (Schwarz and Bilbo, 2012)

In contrast, studies have demonstrated that the inhibition of glutamine metabolism in cancer cells using the DON precursor drug DRP-104 results in an augmentation of the number of NK and NK T-cells within the immune microenvironment, thereby enhancing anti-tumor immunity [121]

Met, with its antioxidant and anti-apoptotic properties, protects the reproductive system and improves sperm count and mobility in diabetic patients with infertility while increasing testosterone hormone levels in blood serum and testicles []