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In other words, exogenous stressors such as heat, injury or infection trigger classic homeostatic negative feedback circuits to restore physiological set points, whereas endogenous stressors such as fear, anxiety and social conflict engage anticipatory circuits (limbic projections) that adjust set-points to meet persistent demands [5]

Its effects on feeding are well documented, however both pharmacological blockade of central IL-1 or IL-6 signaling, and genetic deficiency of IL-1 receptor or IL-6 receptor have resulted in attenuated food intake and weight loss

& Yang, H

Some research suggests that feverfew may help prevent migraine headaches, but results have been mixed