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Race: Lupus is more common among women of African American, Asian, Hispanic, and Native American descent

Thus, where genotype is known, there is a strong case for initiating serum vitamin B 12 monitoring from initiation of metformin treatment in people with the AA genotype but deferring this until 10 years of treatment in the rest of the population who have no other risk factors

The compounds quinolinium scaffold mimics nicotinamides structure, allowing it to compete for the NNMT active site while avoiding interactions with other enzymes