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One study showed that knee injections with BPC-157 helped with arthritis pain in 11 out of 12 subjects, but the study did not use verified survey tools to obtain reliable answers regarding efficacy. BPC-157 is being explored for: Tissue repair Healing of muscle, tendon, ligament and skin wounds Collagen production Neuroinflammation Nerve regeneration Arthritis Gastric ulcers Inflammatory bowel disease (Crohns disease, ulcerative colitis) Leaky gut syndrome Irritable bowel syndrome Had a recent knee surgery

Genetic mutations (e.g., SLC6A1 and SHANK3) have pleiotropic effects on the E/I balance, complicating target selection [112]