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The copper peptides work through cumulative biological signalling GHK-Cu activates Wnt/beta-catenin pathways while AHK-Cu stimulates dermal papilla cell proliferation

In terms of the former this occurs through inhibition of the ubiquinone binding site (atpenin A5, TTFA) or the succinate binding site (malonate) and the latter via autooxidation of flavin (Zhang et al., 1998)

Another commenter voiced concern about establishing restrictive time limits for physicians/NPPs to make POC modifications since none exist currently and they recommend we maintain standing policy until more input is gathered from stakeholders

Consistent with the toxicity of isoniazid in slow acetylators, there is an increased incidence of other drug toxicities in subjects carrying defective alleles, such as lupus erythematosus in patients treated with hydralazine or procainamide (Sim et al., 1988), and haemolytic anemia and inflammatory bowel disease after treatment with sulfasalazine (Chen et al., 2007)