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18 O incorporation into cyanidin (8) Flavan-3,3,4-triol ( 4 ) was first formed in a reaction with 100 mM MOPSO, pH 6.2, 20 mM sodium ascorbate, 1 mM -ketoglutaric acid, 0.4 mM ammonium iron(II) sulfate, 500 M 3,4- cis -leucocyanidin ( 6 ) and 2.5 M At LDOX, which was incubated at 30 C for 15 min at 1,200 rpm using a 3 mm shaking diameter

*Correspondence: Yahui Xu [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers