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AmB is highly efficacious but also has associated toxicity such as includes fever, nausea, vomiting, rigors, hypertension or hypotension, and hypoxia when administered in its free deoxycholate form which has been overcome in its liposomal formulation (Laniado-Laborn and Cabrales-Vargas, 2009

After 48 h of exposure, the IC50 values ranged from 0.9 to 5.5 M in both cancer cell lines, demonstrating strong cytotoxic effects [126]

This paper highlights the role of cysteine underlying the resistance of ovarian cancer cells to hypoxia and carboplatin, which hinders cancer fighting

Astrocytic processes elongate their end feet to contact the brain vasculature, which also envelops neuronal synapses (Araya et al., 2008