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Alprazolam exposure during adolescence induces long lasting dysregulation in reward sensitivity to morphine and second messenger signaling in the VTA NAc pathway Scientific Reports Benzos enhance GABA A receptor activity by increasing the frequency of chloride channel opening, leading to CNS depression. They are first line for status epilepticus (e.g., lorazepam), used for anxiety, panic disorder, alcohol withdrawal Potential Role of Glutathione Antioxidant Pathways in the Pathophysiology and Adjunct Treatment of Psychiatric Disorders PMC Prolonged Alprazolam Treatment Alters Components of Glutamatergic Neurotransmission in the Hippocampus of Male Wistar RatsThe Neuroadaptive Changes following Long Term Benzodiazepine (Mis)Use

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