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For example, zwitterionic-based nanoparticles encapsulated by the mucolytic agent N -acetylcysteine have demonstrated enhanced mucus penetration, whereas the gradual release of N -acetylcysteine cleaves disulfide bonds within the mucus network, locally reducing its viscosity and further facilitating nanoparticle diffusion 194

High-grade glioma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up

In this sense, iPSCs have been successfully generated from LS patients harboring different mutations in mitochondrially encoded genes such as ATP synthase membrane subunit 6 (MT-ATP6) (Galera-Monge et al., 2016

Statistical analysis Each experiment was performed at least three independent times (as specified in each figure legend)