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In the case of AFs, however, it is worthy to point out this fact that the elimination of these mycotoxins in food/feed is impossible, leading to the continuous existence of these risk factors in the environment

Further studies documented that NTBC was a potent inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPD), which catalyzes conversion of 4-hydroxyphenylpyruvate to homogentisic acid 53 (Figure 1)

Current Western medical treatment is based on disease-modifying anti-rheumatic drugs (DMARDs) (4), but there are problems such as insufficient efficacy, drug resistance and adverse reactions, and the clinical outcomes of RA patients are not satisfactory (3)

Ogu UO, Thomas M, Chan F, Vattappally L, Sebastian G, Crouch A, You S, Minniti CP (2021) L-glutamine use in adults with sickle cell disease: clinical trials where success meets reality