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Orally bioavailable lead candidates will be tested in a comprehensive doseranging study to confirm efficacy on obesity and co-morbid endpoints

A recent study has examined the effect of cobalamin supplementation on the outcomes of treatment for feline patients with severe cobalamin deficiency and histories suggesting chronic gastrointestinal disease.5 In this study, serum concentrations of methylmalonic acid normalized following parenteral cobalamin supplementation, indicating that cobalamin deficiency was the cause of the high methylmalonic acid in serum

To test if enhancing the NAD + salvage pathway can inhibit the V-ATPase-autophagy axis, we supplemented the Trp auxotrophic SEY6210 VMA2-AID*-9MYC cells with exogenous niacin, the precursor that fuels the NAD + salvage pathway

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