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Magnitude of associations between wearable sensor-assessed body temperature metrics and depression symptom severity KolmogorovSmirnov D-statistics, which can be considered a measure of effect size, ranged from 0.094 to 0.225 for comparisons of severe symptoms versus WNL for all 4 distal body temperature metrics, while they ranged from 0.014 to 0.056 for comparisons between moderate symptoms versus WNL, and mild symptoms versus WNL (Table 5)

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Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels