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Psychiatry 9:317

Iron chelators such as deferoxamine (DFO) and deferiprone (DFP) have demonstrated therapeutic potential in mitigating disease progression in these conditions

Immunofluorescence microscopy assay RKO or HCT116 cells were incubated with the indicated treatments before permeabilization with 4% paraformaldehyde and 0.3% Triton X-100

TSS pathway activity is suppressed by excess hemin under hypoxia, and the suppression is reversible through DMF treatment The afore findings suggest that supplementing cystine at physiological concentrations is a prerequisite for investigating the function of CBS in SCD erythroblasts