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Loss of methylation of the ICR1 on the paternal allele results in the phenotype of Silver Russell syndrome (SRS) which may also arise from other genetic aberrations that have not yet been linked to the IGF-II production or signaling cascade including maternal uniparental dyssomnia of chromosome 7

The longest animal studies on BPC-157 span approximately 4 weeks to 12 weeks, leaving the safety profile for use extending beyond 3 months entirely undocumented in peer-reviewed literature

The following directions of activity are discussed in the preclinical literature: An important caveat: the mechanisms of DSIP are not fully resolved, and the body of evidence is inconsistent