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The observed decrease of peroxisomal Cit2 activity in aspirin-treated EG110 yeast cells (Table 2) indicates that the glyoxylate cycle, which facilitates transport of acetyl-CoA-derived succinate (a TCA cycle intermediate) to the mitochondria 38 is possibly impaired by aspirin much like the carnitine shuttle pathway

Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features

Curcumin reduces the hepatotoxicity induced by arsenic, cadmium, chromium, copper, lead, and mercury, prevents histological injury, lipid peroxidation, and glutathione (GSH) depletion, maintains the liver antioxidant enzyme status and protects against mitochondrial dysfunction. Curcumin shows tumor inhibiting activity in thyroid cancer