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These factors are enzymes that modify DNA directly or the core histones H2A, H2B, H3, and H4 and some variants [78]

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32 Contrary to early skin model studies, Hernandez et al 32 found only low or inconsistent levels of ROS and AGEs in systemic models, suggesting that DNA damage is not primarily ROS-mediated and instead may occur through mechanisms such as glycation or crosslinking of DNA repair proteins