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doi: 10.1016/j.dsx.2017.08.014

Sleep improvements typically appear within 2-4 weeks, while body composition and performance changes develop over 2-3 months, with continued optimization through 6 months

10.3390/ijms20122863 [PMC free article: PMC6628240] [PubMed: 31212761] [CrossRef] Tutelyan VA, Kravchenko LV, Kuzmina EE (1990)

To examine whether the administration of the Si-based agent alleviates the visceral pain and discomfort associated with UC, we investigated the neuronal activities in the nuclei of the dorsal medulla oblongata [the nuclei of the solitary tract (NST) and the dorsal vagal nuclei (DVN)], and the central amygdala (CeA) using immunostaining for c-Fos, a neuronal active marker