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PMID: 52 WuCXuXShiYLiFZhangXHuangYet al

PMID: 36268413

In contrast to previous viral infections, the viral protein spike coupling with ACE2 results in increased angiotensin II (Ang II) synthesis and stimulation of NADPH oxidase, which in turn enhances oxidative stress mechanisms while also releasing inflammatory mediators (Verdecchia et al., 2020)