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As such, the maintenance of GSH and Prdx2 antioxidants are essential to protect the RBCs from these reactive oxygen species (ROS)

doi:10.4049/jimmunol.1102683

Molecular screening for gene variants may not appear practical or cost-effective traditionally because of the infrastructure and technical expertise required, but advancements are progressively making this more widely accessible in the form of gene chips

One small randomized controlled trial in 450 pregnant women in West Africa, without specified MTHFR genotype but at high risk for preeclampsia, found that supplementation with 15 mg of riboflavin daily was not effective in preventing the condition (29), but the study was likely underpowered to detect a significant effect