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Studies have revealed that aging is a negative regulator of NSPC proliferation, whereas NSPCs could be reactivated in the aged brain ( Liana and Shin-ichiro established that, in response to insult-induced demyelination, NAMPT-mediated NAD+ biosynthesis was critical for NSPC self-renewal, proliferation, and differentiation into oligodendrocytes (Stein and Imai, 2014)