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doi: 10.1128/mBio.00062-19 75 RowanFDochertyNGMurphyMMurphyBCoffeyJCOConnellPR

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Chen found in human melanoma cells that silencing iPLA2 would enhance the sensitivity to p53-mediated ferroptosis without significant effects on cells that usually express iPLA2, suggesting that iPLA2 can inhibit p53-mediated ferroptosis, and p53-driven ferroptosis is independent of GPX4 [41]

162,163 Paradoxically, despite enhanced cystine uptake, MCU-overexpressed PDAC exhibited typical features of ferroptosis caused by cystine deprivation