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We next wanted to confirm that these mTORC1- and ATF4-induced changes were independent of the ISR

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Four prominent mechanisms by which mitochondria communicate with the rest of the cell include the release of cytochrome c to induce cell death, activation of AMP-activated protein kinase (AMPK) to control mitochondrial fission and fusion, production of reactive oxygen species (ROS) to activate transcription factors, and the release of mitochondrial DNA (mtDNA) to activate immune responses 2,3,4,5 (Fig

6 In the brain, that antioxidant support matters for the neural pathways involved in focus, recall, and mental energy