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In the CT group, the REE level did not show an increase as observed in the P group on Day 1 after surgery, when it was significantly lower than in the P group, and remained lower thereafter

Recent studies have found that koumine improves the composition of the GM, primarily by increasing the abundance of Lactobacillus johnsonii and Muribaculaceae, thereby upregulating heme oxygenase-1 (HO-1), B-cell lymphoma-2, and Nrf2 while downregulating Bax, NF-B, and TLR4, and consequently mitigating Concanavalin A-induced autoimmune hepatitis via the gut-liver axis [133]

Melanin is the biochemical compound which is known to produce a tan on the epidermis and hence gives a dull appearance to the skin

J Neurol Neurosurg Psychiatry 81 : 8086