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Ficlatuzumab (AV-299) is a humanized monoclonal anti-HGF IgG1 antibody that enchains to HGF, thereby inhibiting the HGF/c-Met interplay

A region of interest (ROI) was drawn around the mammary fat pad and lung region for each mouse as well as a background ROI outside of the mice, which was subtracted from the total flux and maximum radiance for each mouse