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2018;29:1338 (Epub 2018/05/03)

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At sufficiently high concentrations, IGF-1 and its analogs can also engage the insulin receptor directly, which underlies the recognized hypoglycemic (insulin-like) effects of IGF-1 exposure

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10.1016/j.phrs.2019.104405 129

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This may be involved in abnormal remodeling of cardiac myocytes in hypertensive hypertrophy and failure

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