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For adults or children weighing less than 50 kg, the recommended dosing is 12.5 milligrams/kg every 4 hours or 15 milligrams/kg every 6 hours (maximum individual dose of 750 milligrams), with a maximum total daily dose of 75 milligrams/kg or 3750 milligrams

The outcomes were modeled using multivariable Poisson regression accounting for follow-up time and adjusting for age, sex, race, BMI, Charleston Comorbidity Index, diabetes, smoking, hypertension, COPD, AUDIT-C, severity of COVID-19, and baseline lab results (ALT, AST, ALP, total bilirubin, platelet count, and creatinine)

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Chest (2010) 137(6):14325