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Increased levels of senescence markers and senescent cells have been documented in the I/R injury and UUO models, as well as in kidney biopsy from patients with CKD [72]

The MSH depletion in the thiol-metabolome confirms that MSH is used for protein S- mycothiolation under NaOCl stress

Although these neurobiological alterations may not manifest as overt behavioral symptoms at birth, they can heighten susceptibility to psychiatric disorders later in life [17,18,19]