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Also, there is a lack of metabolites databases, which slows dereplication and often results in many unknown discriminatory features [160]

Water is employed as a single solvent in the reaction, but in order to enhance the solubility of (S)-3-activated hydroxybutyrolactone as the starting material, an organic co-solvent with water may be utilized, such as alcohol of C 1 4 , tetrahydrofuran, or acetonitrile

Food- and microbiota-derived metabolites can be absorbed through the gut and subsequently modulate immune responses and metabolism 5,6,7

It has shown to induce hair regrowth within 2 to 4 months in intact male dogs with a success rate of about 75%