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Taken together, current interventions for ME/CFS remain largely supportive rather than disease-modifying, underscoring the need for future studies to clarify whether targeting chronic stress-related neuroendocrine dysregulation and hippocampal dysfunction may offer more effective therapeutic avenues for cognitive impairment in ME/CFS

The brain is the key organ for regulating fatigue (18), and brain imaging studies have found that the activity and connectivity patterns of brain regions change when patients are fatigued (18,49-51)

Having one variant is less likely to contribute to health issues