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Additional refinements to its structure to limit both phase 1 and phase 2 hepatic metabolism and first pass clearance, to reduce metabolism by gastric enzymes and enhance oral bioavailability, and to diminish polar surface area and overall size to facilitate BBB penetrability are currently in progress

While their evidence bases for neuropathy specifically may be less developed, their mechanisms warrant consideration by researchers building comprehensive nerve repair protocols

Glutathione and Alpha-Lipoic Acid In addition to scavenging free radicals, glutathione is also involved in recycling vitamins C and E.* Alpha-lipoic acid plays an essential role in mitochondrial dehydrogenase reactions, reacts with reactive oxygen species, and interacts with vitamin C and glutathione to recycle vitamin E.* The following table highlights two studies that looked at the effects of co-supplementation with glutathione and alpha-lipoic acid

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