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IKBKE regulates angiogenesis by modulating VEGF expression and secretion in glioblastoma

Our study unravels that compromising lipophagy results in defective trafficking of LDs to mitochondria to support FAO and altered mitochondria dynamics, which interrupt the mitochondrial-PROX1-driven transcriptional circuit, responsible for the expression of lymphangiogenic markers and underscores the intimate, but still elusive link between LD degradation, mitochondrial shape, and metabolism 40

Poly(A) + RNA-selection Total RNA was extracted using TRIzol (Thermo Fisher, 15596018) according to the suppliers protocol

Analysis of differential metabolites in the colon revealed that FMT upregulated 111 metabolites, including Flavin Mononucleotide (FMN), N-Stearoyl Leucine, and Dehydronorketamine, and downregulated 241 metabolites, including Ethylbenzene, Indolelactic acid, Zanamivir, Carnosine, APC, Alpha-Chaconine, and Coumarinic acid (Fig