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We mean this sincerely: the most valuable success stories are the ones that include plateau periods and how patients worked through them

Furthermore, conditioned medium of bovine aortic endothelial cells enhanced vascular smooth muscle Na/K pump activity to a far greater degree in spontaneously hypertensive rats than normotensive controls, with the effect reduced following treatment with PKC inhibitor staurosporine, pointing to a role for PKC in enhanced endothelium-dependent microvascular responses in hypertension (143)

Whether the best term is change or dysplasia is still a matter of debate

doi:10.1038/s41424-018-0052-1 Mori H, Tack J, Suzuki H