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Consistent with this, we observed that KEAP1NRF2 pathway inhibition curtailed the stemness features of chemoresistant MIBC cells, based on the findings that KEAP1 upregulation or NRF2 blockade significantly reduced tumor sphere formation, clonogenic growth and invasiveness, hallmarks of the stem cell-like, therapy-tolerant state

In the CVB3-CP17 structure, CP17 sits upright in the interprotomer pocket due to stacking interactions against Phe76 of VP1 and Phe236 of VP3 from CVB3 29

whether it requires special preservatives, stabilizers etc.)

The surface of this hybrid system is coated with polyoxometalates and polyethylene glycol, which enhances cellular internalization via passive diffusion and effectively inhibits A aggregation[135] (Fig