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Maternal periodontitis expands oral pathobionts like Klebsiella aerogenes , which translocate to the infant gut, disrupt intestinal immunity, and predispose offspring to enteritis ( Gemella and Rothia and decreased Veillonella , with these oral taxa forming distinct ecological clusters in the gut, implying oral-gut migration ( In systemic diseases, oral-gut microbial interactions are prominent

(3) significantly higher baseline ACTH secretion from primary pituitary cell cultures as well as augmented ACTH responses to stimulation with CRH or forskolin (103)

Prog Neurobiol 115:157188

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