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10.1038/cti.2016.17 364

30 Seliktar D

An animal study in a reserpine-induced fibromyalgia rat model found that nano-pregabalin (N-PG) alleviated FM symptoms by enhancing CNS penetration, restoring neurotransmitter balance (Glut, NE, CGRP), increasing antioxidant enzyme activity (e.g., SOD), inhibiting pro-inflammatory transcription factors (e.g., NF-B), and reducing apoptosis by decreasing caspase-3 (Casp-3) activation (36)

The goal of therapy in dermatomyositis is to improve function in activities of daily living as the result of improvement in muscle strength and alleviate the skin rash