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The patients had previous unsuccessful treatments with usual interstitial cystitis care, including avoidance of bladder irritants, treatment of comorbid conditions, including anxiety, depression, fibromyalgia, and endometriosis, and use of medications, including amitriptyline, pentosan polysulfate sodium, phenazopyridine, and methenamine

These include D51.0 (due to intrinsic factor deficiency), D51.1 (selective malabsorption with proteinuria), D51.2 (transcobalamin II deficiency), D51.3 (dietary deficiency), D51.8 (other specified B12 deficiency anemias), and D51.9 (unspecified)