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E., Mahn A., Salgado J

BMJ 348 , g2547 (2014)

This causes increased neuroinflammation in human brain vascular pericytes (Table 1), which further leads to neurovascular unit disruption and immune cell transmigration across the BBB ( TABLE 1 Summary of cocaine- and methamphetamine-induced neurotoxicity based on their effect on the structural integrity of the blood brain barrier and their respective molecular pathways

Thus, dietary substitutions of unsaturated fat for saturated fat, as well as a reduction in consumption of trans fatty acids, is recommended to help lower serum cholesterol and the risk of heart disease