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In a more recent multicenter, randomized, double-blind, placebo-controlled study, supplemental vitamin E (2,000 IU/day

investigated the miR-384-5p/Beclin-1 regulatory axis (a signaling pathway that involves autophagy and stress response), previously identified in atherosclerosis, to explore its role in macrophage autophagy, which seems to have a harmful effect in diabetic encephalopathy ( Oligodendrocyte precursor cells (OPCs) are another important cellular component in the neuroplasticity regulation in DE

2) Angiogenesis, because IGF-I is known to exert significant pro-angiogenic effects, inducing proliferation of microvascular endothelial cells in culture through HIF-1 and VEGF[291]

For instance, a methanolic extract of some fermented soybean foods presented antioxidant compounds of a high activity