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Researchers found that in collegiate swimmers, there was a powerful correlation between cortisol levels and depression, but only during periods of intense training.41 Thus, there appears to be a cumulative stress phenomenon, which may be present at certain times and absent at other times

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In a CS-exposed mouse model (5 days/week for 46 months), genes associated with the TCA cycle, fatty acid oxidation, and redox regulation were compensatorily upregulated in pulmonary epithelial cells, accompanied by mitochondrial morphological and functional abnormalities including reduced cristae number, enlarged volume, decreased membrane potential, and reduced OCR

[21], and self-reported prevalence and past-year asthma attacks in To et al