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Isolated Langendorff-perfused explanted human hearts with extensive infarction or dilated cardiomyopathy demonstrated increased vulnerability to triggering of VT due to cardiac fibrosis facilitating re-entry mechanisms (183, 184)

According to the European Environment Agency (EEA) report, 25% of all reported monitoring sites in European surface waters in 2019 were found to exceed the pesticide limit of 0.1 g /L

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As we suspected that the point mutations we introduced in the RING2 of ANKIB1 might not have aborted its activity to the same extent as was seen in previous studies for other RBR-E3s 22,23,24 , we next expressed an ANKIB1 mutant lacking the entire RING2 domain (ANKIB1RING2) (Extended Data Fig