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Brainstem serotonin and norepinephrine producing nuclei (dorsal raphe nucleus and locus coeruleus, respectively) are vulnerable to cell loss, tau deposition and -synuclein pathology early in normal aging, AD and PD [59, 60, 61] This early involvement of brainstem nuclei is thought to contribute to the high prevalence of depression, anxiety, and sleep disturbance, preceding cognitive decline and motor symptom onset [61,62,63,64,65]

When levels are low, cells are left more vulnerable to oxidative damage accelerating the aging process and increasing the risk of various chronic diseases

CrossRef A Spanish Society joint SECO and SEEDO approach to the Post-operative management of the patients undergoing surgery for obesity R Vilallonga, JL Pereira-Cunill, S Morales-Conde, I Alarcn, I Breton, E Domnguez-Adame, JV Ferrer, A Garcia Ruiz-de-Gordejuela, A Goday, A Lecube, E Martn Garca-Almenta, M Rubio, FJ Tinahones, PP Garca-Luna Obesity Surgery.2019

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