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Consistent with this observation, Gln deprivation causes the epigenetic reprogramming of PCa cells by global changes in histone modifications, e.g., an increase in H3K27me3 methylation levels due to a block in the enzymatic activity of -KG-dependent OGDD enzymes [6]

The relatively low potency of depudecin precluded further work on this compound

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Regulatory factors like heme oxygenase 1 (HO-1) and Poly(rC) binding proteins (PCBPs) also influence iron homeostasis, with HO-1 overexpression reducing ROS and lipid peroxidation to inhibit ferroptosis, as shown by Villalpando-Rodriguez et al