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One hypothesis that can account for the observation of an increased risk for asthma attacks with LABA monotherapy is that patients may feel better when taking long-acting beta agonists, and as a result take either lower doses of inhaled corticosteroids, or no corticosteroids at all

In contrast to the inhibitory effect of PIP 2 depletion, transient PIP 2 hydrolysis was rather found to augment TRPM7 currents (Langeslag et al., 2007)