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Van Bavel N, Issler T, Pang L, Anikovskiy M, Prenner EJ

Our preliminary interpretation is that replacement of Tyr110 indeed affects the interaction with GSH but, as compared to K105A/Y, does not drastically alter the ratio between the steady-state concentrations of the deprotonated and glutathionylated enzyme species E and F, respectively

Due to the risk of respiratory depression with concomitant use of skeletal muscle relaxants and opioids, consider recommending or prescribing an opioid overdose reversal agent [see WARNINGS, DOSAGE AND ADMINISTRATION]

Proteins linked to neutrophil degranulation are more abundant in patients with AH compared to AUD and controls and are associated with disease severity