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Under conditions of cellular stress, injury, or mitochondrial dysfunction, mtDNA can escape into the cytoplasm, where it activates the cGAS (cyclic GMPAMP synthase)STING (stimulator of interferon genes) signaling pathway, or it can be detected extracellularly by Toll-like receptors on immune cells

Acknowledgments We are grateful to Biorender (BioRender.com) for their assistance in graphic illustration

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3, 3-Diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study