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Blockade of glutamate excitotoxicity and its clinical applications

Furthermore, distinct variations in the biosynthesis of the reduced form of glutathione (GSH) and other metabolites related to the cellular antioxidant defense were observed for different untreated Pt(II)-resistant ovarian cancer cell lines, namely, increased levels of GSH and taurine in C200 cells [12] and A2780 [13] cells, respectively, while GSH, hypotaurine and taurine levels were found to be decreased in PEA2 cells [14]

Results accelerated over time At month 1, both treatment groups showed modest gains (10.5 and 11.3 hairs) while placebo declined (-3.6)

On the basis of this rationale, we constructed a comprehensive molecular interaction map of the LPA signaling circuit in OC (Fig