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Neurotransmitters like norepinephrine bind to astrocyte receptors, activating the cAMP pathway to promote glycogen synthesis

Notably, apoptosis is triggered in response to DNA damage resulting in nuclear p53 activation and consequent upregulation of pro-apoptotic proteins and their translocation to mitochondria to trigger the MOMP-mediated pathway

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Zileuton, an FDA-approved oral medication for treating asthma, is an ALOX5 inhibitor that exerts neuroprotective effects by blocking ALOX5-mediated glutamate toxicity and ferroptosis in HT22 cells, a mouse hippocampal cell line [301]