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Particularly, ALDH2 and ALDH3 are reported to have the highest efficacy of 4-HNE detoxification, compared with other isoforms, such as class 1 ALDH, which have a narrow effect on 4-HNE cytotoxicity (13, 39)

These multiprotein complexes play a pivotal role in orchestrating the inflammatory response by enabling caspase-1dependent activation of the potent pro-inflammatory cytokines interleukin-1 (IL-1) and interleukin-18 (IL-18) upon detection of cellular danger signals (233)