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As GSTP1 knockdown significantly increased cisplatin and carboplatin chemosensitivity in A2780 cells, we further investigated whether GSTP1 knockdown in the related platinum-resistant A2780DPP cell line (Behrens et al, 1987) could re-sensitise these drug-resistant cells to platinum-based chemotherapy

Scheduled breaks or cyclic protocols are often used to reduce that risk, but individual response is highly variable

DNA Nanocomposites are also designed to encapsulate systemic cytotoxic agents like cisplatin or doxorubicin that interact with DNA, disrupting the processes of DNA replication and transcription

LPA stimulates cancer cell proliferation primarily by regulating key cell cycle genes in many different cancers, although receptor engagement varies