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Conversely, after APAP injection in hepatic specific PGC-1 overexpressing mice, the high expression of primary ROS scavengers is not able to counteract the hepatic oxidative stress induced by APAP, due to the collapse of GSH reservoir caused by the lowered Gcl-c expression and by the massive utilization of GSH for NAPQI detoxification performed by Glutathione S-Transferases

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One of the key contributors to aging is oxidative stress, which glutathione neutralizes

[DOI] [PMC free article] [PubMed] [Google Scholar] 144.Trabanelli S., Ocadlikova D., Ciciarello M., Salvestrini V., Lecciso M., Jandus C., Metz R., Evangelisti C., Laury-Kleintop L., Romero P., et al